How the kidneys manage magnesium levels
Official title: Magnesium handling by the distal nephron
Funded at Oregon Health & Science University · NIH-11005013 · Data updated 2026-11-12
This study is looking at how your kidneys manage magnesium levels in your body and how certain medications or genetic factors might cause magnesium deficiency, using special imaging techniques to see what's happening in real-time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 20, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $306,623 |
| NIH project number | 5R01DK132066-03 |
| Project ID | NIH-11005013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic conditions affecting magnesium absorption or those on diuretics that may impact magnesium levels.
✕Less likely to help
Patients with normal magnesium levels and no underlying kidney issues are unlikely to benefit from this research.
What this research studies
This research investigates the mechanisms by which the kidneys regulate magnesium levels in the body, focusing on the distal convoluted tubule's role in magnesium reabsorption. It aims to understand how certain medications and genetic conditions affect this process, potentially leading to magnesium deficiency. The study will utilize advanced imaging techniques to observe cellular processes in real-time, providing insights into how magnesium handling can be disrupted. By examining both acute and chronic effects on magnesium absorption, the research seeks to clarify the relationship between sodium reabsorption and magnesium levels.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to magnesium deficiency, enhancing patient health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding magnesium handling in the kidneys, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mccormick, James a — Oregon Health & Science University
- Study coordinator: Mccormick, James a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.