How the KDM5 protein controls genes in unexpected ways
Non-canonical mechanisms of gene regulation by the histone demethylase KDM5
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11180216
Researchers are studying how changes in the KDM5 protein alter gene control in ways that could matter for some cancers and intellectual disability.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11180216 on ClinicalTrials.gov |
What this research studies
This project uses fruit flies to map how KDM5 controls genes separate from its well-known enzyme activity. The team is probing a previously uncharacterized tail region of KDM5 and its connection to the NSL transcriptional activation complex. They combine genetic experiments, protein interaction mapping, and molecular assays in Drosophila to see how these non-enzymatic functions affect development and survival. The goal is to explain how KDM5 changes can lead to disease and point to molecular pathways for future study.
Who could benefit from this research
Good fit: People with cancers or developmental disorders linked to KDM5 changes are the groups most likely to be affected by future therapies based on this research.
Not a fit: Because the work is preclinical in fruit flies, patients needing immediate clinical treatments are unlikely to benefit directly from this grant.
Why it matters
Potential benefit: If successful, the work could reveal new molecular targets or biomarkers that eventually guide better treatments or diagnoses for cancers and KDM5-related intellectual disability.
How similar studies have performed: Previous research has linked KDM5 to cancer and developmental disorders and suggested non-enzymatic roles, but the specific mechanisms and interactions targeted here remain largely unproven.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SECOMBE, JULIE — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: SECOMBE, JULIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers