How the intestine communicates with fat tissue in obesity
Official title: Intestine to adipose tissue interorgan communication in homeostasis and obesity
Funded at Scripps Research Institute, the · NIH-10982316 · Data updated 2026-11-12
This study is looking at how the gut talks to fat tissue and how certain proteins can affect metabolism and obesity, which could help us find new ways to treat weight-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $640,762 |
| NIH project number | 1R01DK136034-01A1 |
| Project ID | NIH-10982316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or related metabolic disorders.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not receive any benefit from this research.
What this research studies
This research investigates the communication between the intestine and adipose tissue, focusing on how secreted proteins influence metabolism and obesity. By studying these interactions, the research aims to identify novel factors that regulate energy storage and metabolism in the body. The approach involves using a specialized biotin labeling system in mice to track proteins secreted from the intestine to fat tissue, which could reveal important insights into metabolic disorders. Patients may benefit from understanding how these processes work and potentially lead to new treatments for obesity-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating obesity and its metabolic complications.
How similar studies have gone: Other research has shown promise in understanding interorgan communication in metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Droujinine, Ilia — Scripps Research Institute, the
- Study coordinator: Droujinine, Ilia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.