How the immune system protects against typhoid and paratyphoid
Immune Mechanisms of Protection in Salmonella Infection in Humans
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11294547
Looking at how adults' immune systems respond to typhoid and paratyphoid bacteria to help create better vaccines.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11294547 on ClinicalTrials.gov |
What this research studies
You would provide blood and other clinical samples from adults who were exposed to wild-type Salmonella Typhi or Paratyphi A or who received vaccine candidates. Researchers will examine B cells, T cells, antibodies, and innate immune signals in those samples with laboratory tests. They will compare responses from people who were protected versus those who developed disease in controlled human infection models and vaccine studies. The aim is to identify immune markers and mechanisms that guide development of multivalent vaccines, especially against Paratyphi A and drug-resistant strains.
Who could benefit from this research
Good fit: Typical participants are healthy adults aged 21 and older, including volunteers from regions where enteric fever is common or adults who have provided samples after infection or vaccination.
Not a fit: Children, pregnant people, and severely immunocompromised individuals are generally excluded and would not directly benefit from participation.
Why it matters
Potential benefit: If successful, this work could speed development of vaccines that prevent typhoid and paratyphoid and reduce antibiotic-resistant infections.
How similar studies have performed: Previous work, including studies of the licensed Ty21a vaccine and controlled human infection models, has identified immune responses linked to protection, but vaccines targeting Paratyphi A are still limited.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SZTEIN, MARCELO B. — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SZTEIN, MARCELO B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.