How the immune system affects the remodeling of blood vessels used for dialysis.
Adaptive immunity regulates arteriovenous fistula remodeling
This study is looking at how the immune system affects the way blood vessels called arteriovenous fistulas (AVFs) develop in patients on dialysis for kidney disease, with the hope of finding better ways to help these blood vessels work well and improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10983772 on NIH RePORTER |
What this research studies
This research investigates how the adaptive immune response influences the remodeling of arteriovenous fistulas (AVFs), which are critical for patients undergoing hemodialysis for end-stage renal disease. By using a mouse model that mimics human AVF maturation, the study explores the biological processes involved in the adaptation of veins to the arterial environment, focusing on factors such as sex differences and chronic kidney disease. The goal is to identify novel strategies to enhance the maturation and functionality of AVFs, ultimately improving patient outcomes during dialysis treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage renal disease who require hemodialysis and are candidates for arteriovenous fistula creation.
Not a fit: Patients who do not require hemodialysis or those with alternative vascular access methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for creating and maintaining arteriovenous fistulas, enhancing the quality of life for patients requiring hemodialysis.
How similar studies have performed: Other research has shown promising results in understanding the role of the immune system in vascular remodeling, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dardik, Alan — Yale University
- Study coordinator: Dardik, Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.