How the immune system affects brain damage after a stroke
Innate immunity and ischemic stroke
This study is looking at how the immune system affects brain damage and healing after a stroke, and it aims to find new treatments that can help reduce inflammation and improve recovery for stroke patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10924116 on NIH RePORTER |
What this research studies
This research investigates the role of the immune system in brain damage and recovery following an ischemic stroke. It focuses on understanding how certain molecules, specifically adenosine deaminase acting on RNA (ADAR1), influence inflammation and gene expression in the brain. By studying animal models, the research aims to identify new anti-inflammatory therapies that could improve outcomes for stroke patients. The goal is to develop treatments that effectively modulate the immune response to reduce brain injury and enhance recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced an ischemic stroke.
Not a fit: Patients who have not suffered a stroke or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and outcomes for stroke patients.
How similar studies have performed: Previous research has shown promise in targeting immune responses in stroke, but this specific approach focusing on ADAR1 and transposable elements is relatively novel.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Cao, Guodong — Veterans Health Administration
- Study coordinator: Cao, Guodong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.