How the immune receptor GPR92 affects insulin-producing cells in obesity-related diabetes
Regulation of GPCR-mediated intercellular communication in islets
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11319819
The project looks at whether a receptor called GPR92 on pancreatic immune cells changes inflammation and insulin production in obesity-related type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11319819 on ClinicalTrials.gov |
What this research studies
Researchers will study immune cells called macrophages that sit next to insulin-producing beta cells and focus on a receptor named GPR92. They will use obese mouse models fed a high-fat diet, GPR92 knockout animals, computer modeling, and lab tests of receptor activity and reported agonists to understand how GPR92 influences islet inflammation. The team will measure insulin levels, beta cell numbers, and inflammatory signals to see how activating or blocking GPR92 affects nearby beta cells. The work aims to identify molecular steps that could be targeted to protect beta cells in obesity-related diabetes.
Who could benefit from this research
Good fit: Adults with obesity-related type 2 diabetes or prediabetes who are interested in research about pancreatic inflammation and beta cell health would be the most relevant candidates.
Not a fit: People with autoimmune type 1 diabetes, non-obesity-related forms of diabetes, or those with severe, longstanding beta-cell loss are less likely to benefit directly from this line of research.
Why it matters
Potential benefit: If successful, this work could point to new treatments that reduce islet inflammation and help preserve insulin-producing beta cells in people with obesity-related type 2 diabetes.
How similar studies have performed: This is a relatively new direction: genetic studies have linked the GPR92 region to diabetes and agonists exist, but its role in islet inflammation and beta-cell function has not been directly tested.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OH, DAYOUNG — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: OH, DAYOUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus