How the immune environment affects Candida albicans in the gut
Dissecting the impact of immune environment on Candida albicans pathogenic potential in the gut
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-11162335
This research looks at how different immune conditions in the gut change whether the common fungus Candida albicans behaves harmlessly or causes disease, aimed at people at risk for gut fungal infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11162335 on ClinicalTrials.gov |
What this research studies
The team will study Candida albicans, a common gut fungus, to see how gut immune factors change its shape and behavior that make it more likely to invade or cause inflammation. They will focus on antibodies called IgA and on immune situations that mimic human immune deficiency or active inflammation. Work will use laboratory experiments and animal models to observe fungal states like hyphae formation and how immune molecules influence those changes. The researchers hope to identify immune-driven switches in the fungus that could become targets for future ways to prevent or reduce Candida-related gut disease.
Who could benefit from this research
Good fit: People who may be most relevant include those with recurrent Candida infections, weakened immune systems, or inflammatory bowel disease who are concerned about fungal contributions to gut inflammation.
Not a fit: Patients without Candida colonization or whose health issues are unrelated to gut fungi are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent or treat Candida-driven gut infections or inflammation by targeting how the immune system influences the fungus.
How similar studies have performed: Laboratory and animal studies have shown immune factors can change Candida behavior, but translating these findings into human treatments is still largely untested and in early stages.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OST, KYLA — UNIVERSITY OF COLORADO DENVER
- Study coordinator: OST, KYLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cellular injury