How the heart adapts to changes in mechanical load
Official title: Post-translational mechanisms of cardiac adaptation during unloading
Funded at Florida State University · NIH-10909398 · Data updated 2026-11-12
This study is looking at how heart cells adjust when they experience different levels of stress, which helps us understand how to keep the heart healthy and could lead to better treatments for heart diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL151825-04 |
| Project ID | NIH-10909398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiovascular diseases or those at risk of developing heart conditions.
✕Less likely to help
Patients with non-cardiovascular related health issues may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which heart cells, known as cardiomyocytes, adapt to changes in mechanical load. It focuses on how these adaptations affect the structure and function of the heart muscle, particularly through the processes of protein modification. The study aims to understand the balance between different chemical modifications of proteins that are crucial for maintaining heart health. By exploring these molecular pathways, the research seeks to uncover insights that could lead to better treatments for cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart diseases by improving our understanding of heart muscle adaptation.
How similar studies have gone: Other research has shown promising results in understanding cardiac adaptations, making this study a continuation of established scientific inquiry.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Solis Ocampo, Christopher — Florida State University
- Study coordinator: Solis Ocampo, Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.