How the gut's immune system interacts with nerve cells
Official title: Neuro-immune interactions at the intestinal surface
Funded at Rockefeller University · NIH-11042210 · Data updated 2026-11-12
This study is looking at how infections and changes in gut bacteria can affect the nerve cells in your digestive system, with the goal of finding ways to help improve gut health and overall well-being, especially as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $611,547 |
| NIH project number | 5R01DK126407-06 |
| Project ID | NIH-11042210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing gastrointestinal disorders, particularly those related to aging or infections.
✕Less likely to help
Patients with gastrointestinal issues unrelated to nerve function or those not experiencing age-related changes may not benefit from this research.
What this research studies
This research investigates the complex interactions between the immune system and nerve cells in the gastrointestinal tract, which is crucial for maintaining health. It focuses on understanding how infections and changes in gut bacteria can lead to the loss of enteric neurons, which are essential for gut function. By studying the mechanisms of neuronal damage and recovery, the research aims to uncover potential therapeutic targets for gastrointestinal disorders. Patients may benefit from insights into how their gut health affects overall well-being, particularly as they age.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal disorders linked to nerve damage and improve gut health in aging populations.
How similar studies have gone: Previous research has shown promising results in understanding gut-brain interactions, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Mucida, Daniel S — Rockefeller University
- Study coordinator: Mucida, Daniel S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.