How the gut's immune system interacts with nerve cells
Neuro-immune interactions at the intestinal surface
This study is looking at how infections and changes in gut bacteria can affect the nerve cells in your digestive system, with the goal of finding ways to help improve gut health and overall well-being, especially as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11042210 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between the immune system and nerve cells in the gastrointestinal tract, which is crucial for maintaining health. It focuses on understanding how infections and changes in gut bacteria can lead to the loss of enteric neurons, which are essential for gut function. By studying the mechanisms of neuronal damage and recovery, the research aims to uncover potential therapeutic targets for gastrointestinal disorders. Patients may benefit from insights into how their gut health affects overall well-being, particularly as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing gastrointestinal disorders, particularly those related to aging or infections.
Not a fit: Patients with gastrointestinal issues unrelated to nerve function or those not experiencing age-related changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal disorders linked to nerve damage and improve gut health in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding gut-brain interactions, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Mucida, Daniel S — Rockefeller University
- Study coordinator: Mucida, Daniel S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.