How the gut senses movement and chemicals
Mechanotransduction in gastrointestinal physiology
This research explores how the gut senses movement and chemicals to understand conditions like irritable bowel syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11141836 on NIH RePORTER |
What this research studies
Many people experience symptoms from gut-brain interaction diseases, such as irritable bowel syndrome (IBS), which are often linked to how the gut senses movement. Our goal is to uncover the specific ways the gut's cells and molecules detect these movements in both healthy individuals and those with conditions like IBS. We've found special cells in the gut that are sensitive to mechanical forces, using a channel called Piezo2 to communicate these sensations. This work aims to understand how these cells also respond to food-related chemicals, influencing gut movement and secretion.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of gut-brain interaction diseases, particularly those experiencing symptoms like IBS.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find this basic science research directly beneficial in the short term.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and treat symptoms in gut-brain interaction diseases like IBS.
How similar studies have performed: This proposal builds on extensive preliminary data and prior discoveries about mechanosensitive cells, suggesting a strong foundation for its novel hypotheses.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Beyder, Arthur — Mayo Clinic Rochester
- Study coordinator: Beyder, Arthur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.