How the gut microbiome affects immune regulation during pregnancy
Immune regulation by the gut microbiome at the maternal-fetal interface
This study is looking at how the bacteria in a pregnant person's gut might affect their immune system and help keep their baby healthy, with the hope of finding ways to prevent problems during pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10907534 on NIH RePORTER |
What this research studies
This research investigates the role of the gut microbiome in regulating the immune system at the maternal-fetal interface, which is crucial for healthy fetal development. It aims to understand how maternal immune tolerance towards the fetus is influenced by changes in the gut microbiome during pregnancy. By using advanced techniques to isolate and analyze immune cells from pregnant mice, the study seeks to uncover the mechanisms that govern fetal immune cell development and the impact of maternal health on pregnancy outcomes. The findings could lead to new insights into preventing pregnancy complications and improving maternal and neonatal health.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women and their developing fetuses, particularly those at risk for pregnancy complications.
Not a fit: Patients who are not pregnant or those with pre-existing severe immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing pregnancy complications and enhancing fetal health.
How similar studies have performed: Other research has shown promising results in understanding the gut microbiome's role in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Zeng, Melody Y — Weill Medical Coll of Cornell Univ
- Study coordinator: Zeng, Melody Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.