How the Gut and Fat Tissue Talk to Each Other in Obesity
Intestine to adipose tissue interorgan communication in homeostasis and obesity
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11181243
This work explores how different organs, especially the gut and fat tissue, communicate to understand how this process goes wrong in people with obesity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11181243 on ClinicalTrials.gov |
What this research studies
Our bodies have a complex network where organs send signals to each other using special proteins. When this communication breaks down, it can lead to health issues like obesity. We want to find new proteins that the gut sends to fat tissue, which could help us understand how fat storage is regulated. By identifying these signals, we hope to uncover new ways to address the metabolic problems associated with obesity. This foundational understanding is crucial for developing future treatments.
Who could benefit from this research
Good fit: This foundational biological work is relevant for anyone affected by obesity or metabolic disorders, as it seeks to understand the underlying mechanisms.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research, as it focuses on fundamental biological discovery.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of obesity and its complications, potentially opening doors for new ways to prevent or treat the condition.
How similar studies have performed: The specific interorgan communication networks being explored are poorly understood, making this a novel approach to identifying key regulatory factors in obesity.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DROUJININE, ILIA — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: DROUJININE, ILIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.