How the gut and brain communicate to regulate body weight and energy balance
Interaction between adipose tissue and central clock via the splanchnic nerve pathway for regulation of energy balance
This study is looking at how fat tissue and the body's internal clock work together to affect weight and energy use, especially after weight loss surgery or when eating at specific times, to find better ways to help people, like veterans, manage obesity and related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10918673 on NIH RePORTER |
What this research studies
This research investigates the interaction between adipose tissue and the body's central clock through the splanchnic nerve pathway, focusing on how these connections influence energy balance and weight management. It explores the effects of bariatric surgery and time-restricted feeding on metabolic processes, particularly how these therapies activate thermogenesis in fat tissue. By understanding these mechanisms, the research aims to identify new strategies for treating obesity and related conditions, especially in populations at higher risk, such as veterans.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals struggling with obesity, particularly veterans who may be at higher risk for obesity-related conditions.
Not a fit: Patients who are not affected by obesity or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for obesity and related metabolic disorders.
How similar studies have performed: Previous studies have shown success with similar approaches, particularly in understanding the metabolic effects of bariatric surgery and time-restricted feeding.
Where this research is happening
Iowa City, United States
- Iowa City VA Medical Center — Iowa City, United States (Active)
Researchers
- Principal investigator: Mokadem, Mohamad — Iowa City VA Medical Center
- Study coordinator: Mokadem, Mohamad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.