How the GSDMA gene affects airway scarring in asthma
GSDMA and Airway Remodeling.
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11134402
Researchers are looking at whether the GSDMA gene causes airway scarring and stiffness that make breathing harder in people with asthma or other airway diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11134402 on ClinicalTrials.gov |
What this research studies
From my perspective, the team studies a gene called GSDMA that may change how airway cells respond to injury. They will compare airway samples and blood from people with and without airway remodeling, measure GSDMA activity, and use laboratory models to see how altering the gene affects inflammation and tissue scarring. The project combines patient samples, genetic testing, and lab experiments to link GSDMA to breathing problems. Results aim to point to ways to prevent or reverse airway stiffening.
Who could benefit from this research
Good fit: Ideal candidates would be people with asthma or other chronic airway diseases, especially those with signs of airway remodeling or persistent breathing problems.
Not a fit: People without airway disease or those whose breathing problems come from non-structural causes are unlikely to receive direct benefit.
Why it matters
Potential benefit: If successful, this research could identify new targets to prevent or reduce airway scarring and improve breathing for people with asthma or chronic airway diseases.
How similar studies have performed: Related studies have linked other gasdermin proteins to inflammation and cell death, but applying GSDMA specifically to airway remodeling is a relatively new and exploratory approach.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROIDE, DAVID H — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BROIDE, DAVID H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.