How the gasdermin protein affects the gut lining in IBD
Mechanisms of gasdermin-dependent epithelial function in inflammatory bowel disease.
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11237306
This project looks at how differences in the gasdermin protein change gut lining cells and could matter for people with inflammatory bowel disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11237306 on ClinicalTrials.gov |
What this research studies
Researchers are studying how the gasdermin B protein works in the cells that line the intestine and how genetic differences in this protein relate to IBD. They will use patient tissue samples, lab-grown intestinal cells, and molecular experiments to see how the protein is cut by immune enzymes, forms pores, or helps kill bacteria. The team will compare normal and disease-associated forms of the protein to understand effects on cell death, wound healing, and barrier function. Results will be linked back to patterns seen in people with Crohn's disease and ulcerative colitis.
Who could benefit from this research
Good fit: Ideal candidates would be adults with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) who can provide biopsy samples or genetic information and are able to visit the research site.
Not a fit: People who do not have IBD or whose disease is caused by factors unrelated to gasdermin function are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could identify new ways to protect or repair the intestinal barrier and suggest treatments tailored to a person’s GSDMB genetic type.
How similar studies have performed: Previous studies have linked GSDMB to IBD and shown cellular effects, but turning those findings into patient therapies is still a relatively new area.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIZARRO, THERESA TORRES — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: PIZARRO, THERESA TORRES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.