How the fungus Candida albicans interacts with the bacteria Salmonella in the gut
Official title: Inter-kingdom interactions of Salmonella Typhimurium and Candida albicans in the gut
Funded at University of Illinois at Chicago · NIH-10983774 · Data updated 2026-11-12
This study is looking at how a common fungus and a type of bacteria interact in the gut, especially in people with gut inflammation, to see if their relationship affects infections and antibiotic resistance, which could help improve treatment options for those dealing with multiple infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | November 9, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $532,995 |
| NIH project number | 5R01AI175223-02 |
| Project ID | NIH-10983774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have experienced gastrointestinal infections or inflammatory bowel diseases.
✕Less likely to help
Patients without gastrointestinal issues or those not colonized by Candida albicans may not benefit from this research.
What this research studies
This research investigates the interactions between the fungus Candida albicans and the bacteria Salmonella Typhimurium in the human gut. It aims to understand how the presence of Candida can influence Salmonella infections, particularly in patients with gut inflammation. The study will involve analyzing how these two pathogens coexist and affect each other's behavior, potentially leading to increased antibiotic resistance. By examining these interactions, the research seeks to uncover new insights into treating polymicrobial infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for infections caused by multiple pathogens in the gut.
How similar studies have gone: Previous research has indicated that understanding polymicrobial interactions can lead to significant advancements in treating complex infections, suggesting this approach has potential for success.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Behnsen, Judith — University of Illinois at Chicago
- Study coordinator: Behnsen, Judith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.