How the extracellular matrix influences eye development
Stepwise Coordination of Eye Morphogenesis by Extracellular Matrix
This study is looking at how the supportive structure around eye cells helps shape the eye during its development, which could help us understand why some babies are born with vision problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10778631 on NIH RePORTER |
What this research studies
This research investigates the role of the extracellular matrix (ECM) in the development of the eye, particularly during the formation of the optic cup, which is crucial for proper eye structure. By utilizing advanced imaging and computational methods, the study aims to uncover how different components of the ECM affect cell movement, survival, and signaling during eye morphogenesis. The research focuses on understanding the molecular mechanisms that govern these processes, which could lead to insights into developmental defects that cause visual impairment in newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns or children with developmental eye disorders, particularly those with conditions like coloboma.
Not a fit: Patients with acquired eye conditions or those unrelated to developmental defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for congenital eye defects that result in visual impairment.
How similar studies have performed: Other research has shown promising results in understanding the role of the extracellular matrix in organ development, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Kwan, Kristen M — University of Utah
- Study coordinator: Kwan, Kristen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.