How the extracellular matrix influences cell movement in cancer and development
Regulation of a self-generated attractant gradient by the extracellular matrix
This study looks at how certain cells move by exploring how their surroundings help guide them, using zebrafish embryos to see how a specific group of cells travels, which is important for things like development and cancer spread.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10996721 on NIH RePORTER |
What this research studies
This research investigates how cells migrate by studying the role of the extracellular matrix in creating attractant gradients that guide cell movement. Using zebrafish embryos as a model, the research focuses on the migration of a specific group of cells known as the posterior lateral line primordium. The study aims to understand how these cells generate and maintain a signaling gradient that directs their movement, which is crucial for processes like embryonic development and cancer metastasis. By manipulating genetic factors and observing cell behavior in real-time, the research seeks to uncover the mechanisms behind effective cell migration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers that exhibit aggressive metastasis or those interested in the biological mechanisms of cell movement.
Not a fit: Patients with non-cancerous conditions or those not affected by diseases related to cell migration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling cancer cell migration and improving treatments for cancer metastasis.
How similar studies have performed: Other research has shown promising results in understanding cell migration mechanisms, but this specific approach focusing on the extracellular matrix and its regulation of attractant gradients is relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: O'keeffe, Catherine Ann — New York University School of Medicine
- Study coordinator: O'keeffe, Catherine Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.