How the extracellular matrix affects bone growth and healing in children
Official title: Extracellular Matrix Impacts Angiogenesis and Growth Plate Repair
Funded at Colorado School of Mines · NIH-10793583 · Data updated 2026-11-12
This study is looking at how injuries to the growth plate in kids can affect their bone growth and aims to find new ways to help heal these injuries and prevent problems like growth deformities.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado School of Mines NIH-funded |
| Lab location | 1 site (Golden, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $185,047 |
| NIH project number | 5R21AR081522-02 |
| Project ID | NIH-10793583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 who have sustained growth plate injuries.
✕Less likely to help
Patients who are older than 21 or who do not have growth plate injuries may not benefit from this research.
What this research studies
This research investigates how injuries to the growth plate in children can lead to serious complications in bone growth. The focus is on understanding the role of the extracellular matrix in regulating blood vessel formation and tissue repair in the growth plate. By exploring innovative treatment strategies that target these biological processes, the research aims to prevent the formation of unwanted bony tissue that can cause growth deformities. The approach involves using biomaterials to modulate the healing environment and improve outcomes for pediatric patients with growth plate injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent growth plate injuries from causing long-term bone growth issues in children.
How similar studies have gone: Previous research has shown promise in using biomaterials to influence tissue repair, suggesting that this approach could be effective.
Where this research is happening
-
Colorado School of Mines
Golden, United States Active
Researchers
- Principal investigator: Krebs, Melissa — Colorado School of Mines
- Study coordinator: Krebs, Melissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.