How the Epstein Barr virus affects gene activity in HIV/AIDS patients
EBV reactivation causes widespread host de novo promoter transcription and transcriptional interference
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-10880346
This study is looking at how the Epstein Barr virus might increase the risk of lymphoma in people living with HIV/AIDS, by exploring how the virus can become active and affect the body, which could lead to cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-10880346 on ClinicalTrials.gov |
What this research studies
This research investigates the Epstein Barr virus (EBV) and its role in increasing the risk of lymphoma among individuals with HIV/AIDS. It focuses on how EBV can switch from a dormant state to an active one, leading to viral replication and potential cancer development. By examining the interactions between the virus and host cell processes, the study aims to understand how EBV influences gene expression and contributes to the heightened cancer risk in HIV-infected individuals. The research employs advanced biological models to analyze these mechanisms and their implications for patient health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who are at risk for EBV-associated lymphomas.
Not a fit: Patients who do not have HIV/AIDS or are not at risk for EBV-related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for lymphoma in HIV/AIDS patients.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between viruses and host cells, indicating potential for success in this area.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLEMINGTON, ERIK K — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: FLEMINGTON, ERIK K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: AIDS associated cancer, AIDS related cancer, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus