How the environment affects the movement of cancer cells before they spread.
Biophysical roles of pre-metastatic niche evolution on transport of circulating tumor cells
['FUNDING_U01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-10806934
This study is looking at how cancer cells from breast tumors interact with their surroundings before they spread to other parts of the body, focusing on how platelets and blood flow might help them settle in new places, which could lead to new ways to prevent cancer from spreading.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10806934 on ClinicalTrials.gov |
What this research studies
This research investigates how circulating tumor cells (CTCs) interact with their environment before spreading to other parts of the body, particularly in breast cancer. It focuses on the role of platelets and changes in blood flow dynamics that may help these cancer cells settle in new locations. By using mouse models, the study aims to understand the physical and biological factors that contribute to the formation of a pre-metastatic niche, which could lead to new prevention strategies. The findings could reveal critical insights into how to stop cancer from spreading.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer who may be at risk of metastasis.
Not a fit: Patients with non-cancerous conditions or those whose cancer has already metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the spread of breast cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microenvironment in cancer metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, XUEWU — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: LIU, XUEWU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.