How the environment affects ovarian cancer spread and treatment.
Regulation of ovarian cancer metastasis by microenvironment-induced chromatin accessibility and c-Jun activation.
This study is looking at how ovarian cancer cells move and spread in the body by using a special lab model that acts like human tissue, with the goal of finding new ways to help improve treatment for people with advanced ovarian cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11133344 on NIH RePORTER |
What this research studies
This research investigates how ovarian cancer cells interact with their surrounding environment to spread throughout the body. By using a 3D culture model that mimics human tissue, researchers aim to understand the mechanisms that allow cancer cells to metastasize, particularly focusing on the role of chromatin accessibility and the transcription factor c-Jun. The study combines laboratory experiments with analysis of patient tumors to identify potential new targets for therapy that could improve treatment outcomes for patients with advanced ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced ovarian cancer who are experiencing metastasis.
Not a fit: Patients with early-stage ovarian cancer or those whose cancer has not metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies specifically targeting ovarian cancer metastasis, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Other research has shown promise in understanding cancer metastasis through similar approaches, but this specific focus on chromatin accessibility and c-Jun in ovarian cancer is relatively novel.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Mitra, Anirban Kumar — Indiana University Indianapolis
- Study coordinator: Mitra, Anirban Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.