How the endocannabinoid system affects stress responses in the brain
Endocannabinoid Modulation of the Habenular Stress Response
['FUNDING_R01'] · WASHINGTON STATE UNIVERSITY · NIH-10954267
This study is looking at how stress affects a part of the brain related to depression, hoping to find new ways to help people who struggle with depression that doesn't get better with usual treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-10954267 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the endocannabinoid system in the lateral habenula, a brain region linked to stress and depression. It aims to understand how chronic stress alters this system and contributes to depression-related behaviors. By studying both clinical populations and animal models, the research seeks to uncover potential therapeutic strategies for restoring normal brain function in individuals with treatment-resistant depression. The approach includes examining the effects of stress on brain signaling and behavioral responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing major depression, especially those with treatment-resistant symptoms.
Not a fit: Patients with mild stress or non-depressive conditions may not receive significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals suffering from major depression, particularly those who do not respond to existing therapies.
How similar studies have performed: Previous research has shown promising results in understanding the role of the endocannabinoid system in stress and depression, suggesting that this approach could yield valuable insights.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCLAUGHLIN, RYAN JOSEPH — WASHINGTON STATE UNIVERSITY
- Study coordinator: MCLAUGHLIN, RYAN JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.