How the Ebola and Marburg VP40 protein helps viruses assemble and leave cells
Computational and Biophysical Analysis of the Filovirus Matrix Protein System
Researchers are using computer models and lab-grown virus-like particles to learn how a key viral protein called VP40 helps Ebola and Marburg viruses build and bud from infected cells, which could help people at risk of these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11146380 on NIH RePORTER |
What this research studies
From a patient perspective, the team combines computer simulations with experimental and structural biophysics to watch how VP40 protein copies join together and interact with cell membranes. They use virus-like particles made in safer lab conditions so they can observe assembly and budding outside of high-containment (BSL-4) labs. The researchers will map the protein’s interactions and dynamics to pinpoint steps that could be blocked by drugs or antibodies. Their methods include computational modeling, biochemical experiments, and structural analysis to reveal the physical rules behind viral assembly.
Who could benefit from this research
Good fit: Ideal candidates are people affected by or interested in filovirus research (for example survivors, exposed contacts, or those willing to donate blood or samples) who might participate in related specimen collection or future clinical studies.
Not a fit: People with no exposure risk to Ebola or Marburg or whose health issues are unrelated to viral infection are unlikely to receive direct benefit from this basic laboratory-focused project.
Why it matters
Potential benefit: If successful, this work could reveal new targets for drugs or therapies that block virus assembly and reduce the risk of severe Ebola or Marburg disease.
How similar studies have performed: Previous VP40 and virus-like particle studies have clarified protein behaviors and assembly steps, but turning that knowledge into proven treatments has not yet been achieved.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Stahelin, Robert Virgil — Purdue University
- Study coordinator: Stahelin, Robert Virgil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.