How the cytoskeleton affects calcium regulation in muscle cells
Cytoskeletal Regulation of SERCA in Muscle
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10889008
This study is looking at how certain proteins in muscle cells help control calcium levels, which are important for muscles to work properly, and it hopes to find new ways to improve muscle function for people with muscle-related issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10889008 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the cytoskeleton in regulating calcium levels in muscle cells, which is crucial for muscle contraction and relaxation. It focuses on how proteins like obscurin and small ankyrin 1 interact with the sarco-endoplasmic reticulum calcium ATPase (SERCA) to modulate calcium uptake and release. By understanding these interactions, the research aims to uncover mechanisms that could enhance muscle function and performance. Patients may benefit from insights that could lead to new treatments for muscle-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with muscle disorders or conditions that affect muscle function.
Not a fit: Patients with non-muscle related conditions or those not experiencing muscle dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for muscle disorders by enhancing our understanding of calcium regulation in muscle cells.
How similar studies have performed: Other research has shown promising results in understanding calcium regulation in muscle cells, suggesting that this approach could lead to significant advancements.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLOCH, ROBERT J — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: BLOCH, ROBERT J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.