How the CPSF6 protein affects HIV infection in CD4 T cells
Deciphering the Role of CPSF6 in HIV Infection
This project looks at whether the human protein CPSF6 controls how HIV infects CD4 T cells and alters the immune response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11137114 on NIH RePORTER |
What this research studies
This work studies a human protein called CPSF6 and how it shapes HIV infection and the cell's antiviral defenses. Researchers will use human CD4+ T cells in the lab, removing or altering CPSF6 and measuring HIV replication and the activation of interferon-stimulated genes. They will also examine whether HIV changes CPSF6 function and test related cellular pathways that might control infection. The experiments are done on cells rather than testing new treatments in people, but results could point to future therapy targets.
Who could benefit from this research
Good fit: Ideal participants would be people living with HIV or healthy volunteer blood donors willing to provide blood samples for CD4+ T cell studies.
Not a fit: People hoping for immediate changes to their HIV treatment are unlikely to receive direct benefit because this is laboratory research rather than a clinical therapy trial.
Why it matters
Potential benefit: If successful, the project could reveal new targets to boost immune control of HIV or guide development of antiviral strategies.
How similar studies have performed: Prior studies have produced mixed results—some experiments suggested CPSF6 restricts HIV while recent primary CD4+ T cell work showed increased viral replication when CPSF6 is lost.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Hultquist, Judd F — Northwestern University
- Study coordinator: Hultquist, Judd F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.