How the control of DNA packaging affects cell growth during animal development
Epigenetic Control of the Cell Cycle During Animal Development
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10928250
This study is looking at how our cells make and organize DNA during their growth cycle, which is really important for healthy development, and it could help us understand what goes wrong in diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10928250 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate DNA replication and packaging during the cell cycle, which is crucial for normal animal development. By focusing on how chromatin assembly influences genome replication, the study aims to uncover the processes that ensure accurate cell division and growth. The research will explore the synthesis of histone proteins, which are essential for DNA organization, and how their production is coordinated with the cell cycle. This understanding could provide insights into the disruptions that lead to diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal cell growth or cancer.
Not a fit: Patients with stable, non-cancerous conditions or those not experiencing issues with cell proliferation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by improving our understanding of cell growth regulation.
How similar studies have performed: Previous research has shown that understanding chromatin dynamics can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DURONIO, ROBERT J — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: DURONIO, ROBERT J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers