How the common gut yeast Candida affects Salmonella infections
Inter-kingdom interactions of Salmonella Typhimurium and Candida albicans in the gut
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-11290289
This project looks at whether the common gut yeast Candida albicans changes how Salmonella causes gut infections in adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-11290289 on ClinicalTrials.gov |
What this research studies
If you carry Candida in your gut or have had Salmonella, this work explores whether the two microbes interact and make infections harder to treat. Researchers will use clues from a large clinical dataset that found links between Candida colonization and Salmonella together with laboratory models that mimic the gut. They will study mixed biofilms, microbial binding, and how these interactions affect antibiotic resistance and gut inflammation. The goal is to understand the biology so new prevention or treatment ideas can be developed.
Who could benefit from this research
Good fit: Adults who have had Salmonella gastroenteritis or who are known to carry Candida albicans in their gut would be most relevant to this work.
Not a fit: People under 21, those without gut Candida colonization, or those with infections not involving Salmonella are unlikely to gain direct benefit from this research.
Why it matters
Potential benefit: If successful, this research could reveal new ways to prevent or treat Salmonella gut infections that happen alongside Candida colonization.
How similar studies have performed: A recent large clinical analysis showed an association between Candida colonization and higher Salmonella infection rates, but direct lab studies on the mechanism are still new.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEHNSEN, JUDITH — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: BEHNSEN, JUDITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.