How the clock protein BMAL1 affects brain function and memory.
Biochemical and Biophysical Tuning of Presynaptic Function by the Clock Protein BMAL1
['FUNDING_FELLOWSHIP'] · HARVARD MEDICAL SCHOOL · NIH-10925175
This study is looking at how a protein called BMAL1 helps control brain connections that are important for learning and memory, which could help us understand issues related to Alzheimer's disease and autism.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10925175 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the clock protein BMAL1 in regulating synaptic function in the brain, which is crucial for learning and memory. By examining how BMAL1 interacts with synaptic components and influences the timing of neurotransmitter release, the study aims to uncover the biochemical and biophysical mechanisms behind these processes. The research utilizes advanced techniques to analyze the localization and function of BMAL1 at synapses, particularly in relation to circadian rhythms. Patients may benefit from insights gained into how disruptions in these mechanisms could contribute to conditions like Alzheimer's disease and autism.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with Alzheimer's disease, autism spectrum disorders, or other conditions affecting cognitive function.
Not a fit: Patients with acute cognitive impairments unrelated to circadian rhythms or synaptic function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory and cognitive function in patients with neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILETTE, NICOLE MARIE — HARVARD MEDICAL SCHOOL
- Study coordinator: GILETTE, NICOLE MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome