How the cell's nuclear membrane changes during and after cell division
Dynamic Events at the Nuclear Envelope during Mitosis and Interphase
Researchers are looking at how the membrane around the cell's nucleus forms and remodels during cell division and in between divisions to better understand links to cancer and aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11146329 on NIH RePORTER |
What this research studies
From your perspective, the team watches live cells with high-resolution imaging and uses molecular tools to track proteins and membranes as the nucleus breaks down and reforms during division. They focus on distinct regions of the assembling nuclear envelope where pore formation and microtubule interactions occur, and they test how altering envelope components affects chromosome protection. Experiments use cultured mammalian cells and genetic or biochemical manipulations to recreate and probe envelope defects. The goal is to connect basic nuclear envelope mechanisms to genomic instability seen in cancer and age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates would be people with cancers known to show genomic instability or patients willing to donate tumor or tissue samples for molecular studies.
Not a fit: People without cancer or without interest in donating tissue samples are unlikely to gain direct benefit from participating in this lab-focused research.
Why it matters
Potential benefit: If successful, this work could pinpoint mechanisms that lead to genomic instability and suggest new targets to prevent or treat some cancers and aging-related conditions.
How similar studies have performed: Similar cell biology and imaging approaches have clarified nuclear envelope behavior in cells, but directly linking these mechanisms to human cancer outcomes is still an emerging area.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Ullman, Katharine S — Utah State Higher Education System--University of Utah
- Study coordinator: Ullman, Katharine S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.