How the CEBPB protein affects aging
Dissecting CEBPB Function with Synthetic Biology and Imaging
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11235120
Researchers are using engineered cells and advanced imaging to see how two forms of the CEBPB protein change with age and could be targeted to reduce aging-related decline.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11235120 on ClinicalTrials.gov |
What this research studies
From a patient perspective, the team will reprogram and tag the two main CEBPB forms so they can watch their behavior inside cells with high-resolution imaging. They will test how chemical tags (like acetylation and phosphorylation) and partnering proteins change CEBPB activity using engineered gene systems and biochemical assays. Experiments will use lab-grown cells and model systems to link molecular changes in CEBPB to cellular features tied to aging. The goal is to produce knowledge that could point toward therapies that safely modify CEBPB activity to improve health as people age.
Who could benefit from this research
Good fit: Ideal candidates are adults interested in aging research who might donate blood or tissue samples now or consider future clinical trials targeting CEBPB.
Not a fit: People seeking immediate clinical treatments or those without age-related concerns are unlikely to receive direct benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could point to new ways to slow aging or reduce age-related health problems by targeting CEBPB isoforms.
How similar studies have performed: Prior lab studies in cells and model organisms showed that altering LIP levels can affect lifespan and health, but applying these findings safely in humans has not yet been achieved.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIONNET, TIMOTHEE — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: LIONNET, TIMOTHEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.