How the brain's internal clock changes its structure and connections
Circadian Structural Plasticity in Central Pacemakers
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10849698
This study is looking at how the brain's internal clock changes over time and affects our daily rhythms, using mice and fruit flies to see how their brain connections adapt, which could help us understand how our biological clock impacts our health and behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10849698 on ClinicalTrials.gov |
What this research studies
This research investigates how the brain's internal clock, specifically in the suprachiasmatic nucleus, adapts its structure and connectivity over time. By using advanced genetic techniques in mice and fruit flies, the study aims to understand the changes in neuron connections that occur in response to circadian rhythms. The researchers will employ cutting-edge 3D imaging methods to visualize these structural changes and assess their functional implications on behavior. This work could provide insights into how our biological clock influences various physiological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing circadian rhythm disruptions, such as those with sleep disorders or shift work-related issues.
Not a fit: Patients with conditions unrelated to circadian rhythms or those under 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing circadian rhythm-related disorders, improving overall health and well-being.
How similar studies have performed: Other research has shown promising results in understanding circadian rhythms and their impact on health, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE LA IGLESIA, HORACIO O — UNIVERSITY OF WASHINGTON
- Study coordinator: DE LA IGLESIA, HORACIO O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.