How the brain's clock influences reproduction through specific neurons
Official title: Suprachiasmatic nucleus to kisspeptin circuit in the circadian control of reproduction
Funded at Kent State University · NIH-11012910 · Data updated 2026-11-12
This study is looking at how a part of the brain that keeps track of day and night helps control when women ovulate, focusing on special brain cells that respond to these daily rhythms, and it aims to improve our understanding of reproductive health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kent State University NIH-funded |
| Lab location | 1 site (Kent, United States) |
| Project start | April 5, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $342,000 |
| NIH project number | 5R01HD109337-03 |
| Project ID | NIH-11012910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals experiencing reproductive issues related to timing, such as infertility or irregular ovulation.
✕Less likely to help
Patients with reproductive issues not related to circadian rhythms or those who have already undergone irreversible reproductive procedures may not benefit from this research.
What this research studies
This research investigates the role of the brain's circadian clock in regulating reproductive functions, particularly focusing on how specific neurons called kisspeptin neurons interact with signals from the suprachiasmatic nucleus (SCN). The study aims to understand how these neurons control the timing of ovulation by responding to daily rhythms. By examining the electrical activity of these neurons and their connections with other brain regions, the research seeks to uncover the mechanisms that ensure reproductive events occur at optimal times. This could lead to insights into reproductive health and timing-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for reproductive disorders and better understanding of fertility timing.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in reproductive health, indicating that this approach has potential for significant findings.
Where this research is happening
-
Kent State University
Kent, United States Active
Researchers
- Principal investigator: Piet, Richard — Kent State University
- Study coordinator: Piet, Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.