How the brain's basal forebrain affects sensory processing
Mechanisms of basal forebrain control over sensory processing
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10906133
This study is looking at how a part of the brain called the basal forebrain helps us process smells and other senses, especially when we're motivated or paying attention, which is important for people with Alzheimer's disease who often struggle with these senses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10906133 on ClinicalTrials.gov |
What this research studies
This research investigates how the basal forebrain influences sensory experiences and cognitive functions by modulating sensory processing based on behavioral states such as motivation and attention. It focuses on understanding the neural circuits involved in these processes, particularly in relation to olfactory processing, which is often impaired in conditions like Alzheimer's disease. Using advanced imaging techniques, the study aims to explore how cholinergic signaling in the basal forebrain affects the brain's response to smells and other sensory inputs. This could lead to insights into the underlying mechanisms of cognitive deficits associated with neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders who experience sensory processing deficits.
Not a fit: Patients without cognitive impairments or those not diagnosed with neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving sensory processing and cognitive function in patients with Alzheimer's disease and other neurodegenerative conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of the basal forebrain in sensory processing, suggesting that this approach could yield valuable insights.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOSS, ELIZABETH HANSON — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: MOSS, ELIZABETH HANSON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease