How the brain's 3D genome helps store long-term memories
From 3D genomes to neural connectomes: Higher-order chromatin mechanisms encoding long-term memory
This project looks at whether the way DNA folds inside brain cells helps people form and keep memories over many years.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11445511 on NIH RePORTER |
What this research studies
Researchers are studying how DNA and its associated proteins fold into 3D shapes inside neurons and how those shapes change when neurons are active. They will use new molecular and computational tools, including CRISPR-based screens and engineered architectural proteins, in cells and animal models and by examining disorders like fragile X syndrome. The team will map long-range DNA loops and chromatin domains to see if these structures carry lasting molecular traces of experience. Results will be compared across normal development, neuronal stimulation, reprogrammed cells, and disease models to link genome structure with memory function.
Who could benefit from this research
Good fit: People with genetic memory conditions such as fragile X syndrome or repeat-expansion disorders, or individuals willing to donate tissue or join related studies, would be the most likely candidates to participate or contribute.
Not a fit: People whose memory problems are solely due to normal aging or non-genetic brain injury may not see direct benefits from this basic genomic research in the near term.
Why it matters
Potential benefit: If successful, this work could point to new targets for treatments that restore or preserve memory by correcting genome folding in affected brain cells.
How similar studies have performed: Prior studies have linked chromatin loops to neuron activity and to disease, but applying 3D genome engineering to long-term memory is a novel and early-stage approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Phillips-Cremins, Jennifer Elizabeth — Washington University
- Study coordinator: Phillips-Cremins, Jennifer Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.