How the brain signals energy needs during learning and memory

Food for thought: a virus-like signal for the energetic demands of higher cognitive functions

['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10927337

This study is looking at how the brain tells the body to use energy when we're thinking hard or learning new things, and it's especially for people who might be struggling with memory or focus due to weight or metabolic issues.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF COLORADO DENVER (nih funded)
Locations1 site (Aurora, UNITED STATES)
Trial IDNIH-10927337 on ClinicalTrials.gov

What this research studies

This research investigates how the brain communicates its energy demands during cognitive activities like learning and memory. It explores the role of virus-like particles that are produced in the brain when these higher cognitive functions occur, and how these particles may signal fat storage tissues to release energy. By understanding this process, the research aims to uncover the mechanisms behind cognitive impairments associated with energy imbalances, such as those seen in obesity and metabolic syndromes. The approach involves studying the interactions between brain activity and energy mobilization from body fat.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals experiencing cognitive impairments or those with metabolic syndromes such as obesity.

Not a fit: Patients without cognitive impairments or metabolic issues may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for improving cognitive function and addressing cognitive decline related to obesity and metabolic disorders.

How similar studies have performed: While the specific approach of using virus-like particles in this context is novel, related research has shown success in understanding brain energy dynamics and cognitive function.

Where this research is happening

Aurora, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.