How the brain regulates body temperature during extreme heat

Central thermoregulatory mechanisms during heat stress

NIH-funded research Scintillon Institute for Photobiology · NIH-11056686

This study is looking at how our brains help us cool down when we get too hot, focusing on certain brain cells that kick in during high temperatures, and it’s designed for anyone interested in how our bodies handle heat stress.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionScintillon Institute for Photobiology NIH-funded
Lab location1 site (San Diego, United States)
Project IDNIH-11056686 on NIH RePORTER

What this research studies

This research investigates the brain's mechanisms for regulating body temperature when exposed to extreme heat. It focuses on specific neurons activated during high core body temperatures and their role in triggering heat loss responses. Using advanced techniques like genetic tools and optogenetics, the study aims to map the neural pathways involved in thermoregulation. By understanding these processes, the research seeks to uncover new insights into how the body copes with heat stress.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals who experience heat stress or related conditions, such as athletes or those working in hot environments.

Not a fit: Patients with stable body temperature regulation and no history of heat-related illnesses may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new treatments for heat-related illnesses and improve our understanding of thermoregulation.

How similar studies have performed: Other research has shown promising results in understanding thermoregulation, but this specific approach is relatively novel.

Where this research is happening

San Diego, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.