How the brain regulates body temperature during extreme heat
Official title: Central thermoregulatory mechanisms during heat stress
Funded at Scintillon Institute for Photobiology · NIH-11056686 · Data updated 2026-11-12
This study is looking at how our brains help us cool down when we get too hot, focusing on certain brain cells that kick in during high temperatures, and it’s designed for anyone interested in how our bodies handle heat stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scintillon Institute for Photobiology NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | June 15, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $432,000 |
| NIH project number | 5R01NS124844-04 |
| Project ID | NIH-11056686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who experience heat stress or related conditions, such as athletes or those working in hot environments.
✕Less likely to help
Patients with stable body temperature regulation and no history of heat-related illnesses may not benefit from this research.
What this research studies
This research investigates the brain's mechanisms for regulating body temperature when exposed to extreme heat. It focuses on specific neurons activated during high core body temperatures and their role in triggering heat loss responses. Using advanced techniques like genetic tools and optogenetics, the study aims to map the neural pathways involved in thermoregulation. By understanding these processes, the research seeks to uncover new insights into how the body copes with heat stress.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heat-related illnesses and improve our understanding of thermoregulation.
How similar studies have gone: Other research has shown promising results in understanding thermoregulation, but this specific approach is relatively novel.
Where this research is happening
-
Scintillon Institute for Photobiology
San Diego, United States Active
Researchers
- Principal investigator: Tabarean, Iustin Virgil — Scintillon Institute for Photobiology
- Study coordinator: Tabarean, Iustin Virgil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.