How the brain protein TTYH1 helps move fats and ApoE in support cells and affects brain aging and Alzheimer’s

Who could benefit from this research

What this research studies

From a patient’s perspective, researchers are focusing on a brain protein called TTYH1 and how it helps astrocytes (brain support cells) handle fats and release ApoE, a protein tied to Alzheimer’s risk. They will use human primary astrocytes, gene expression (transcriptomics), and lipid profiling (lipidomics) alongside fruit fly models to see what happens when TTYH1 is missing or altered. Laboratory cell biology experiments will examine autophagy and lipid droplet breakdown in glia and compare findings between healthy and Alzheimer’s-affected samples. The team aims to map the molecular steps linking lipid changes to cell malfunction that could point to future therapeutic targets.

Why it matters

Where this research is happening

• Rutgers the State Univ of Nj Newark
  Newark, United States Active

Researchers

• Principal investigator: Wong, Ching-on — Rutgers the State Univ of Nj Newark
• Study coordinator: Wong, Ching-on

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.