NIH-funded research R01 grant

How the brain processes social and non-social rewards

Official title: Prefrontal circuits in processing social versus non-social rewards

Funded at Emory University · NIH-11019723 · Data updated 2026-11-12

This study looks at how the brain reacts to social rewards, like spending time with friends, versus non-social rewards, like enjoying a tasty snack, to better understand why some people with Autism Spectrum Disorder (ASD) may struggle with social motivation, and it hopes to find ways to improve social interactions for them.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionEmory University
NIH-funded
Lab location1 site (Atlanta, United States)
Project startApril 3, 2023
Project endJanuary 31, 2028
Funding year2025
Award (this year)$322,287
NIH project number5R01MH130755-03
Project IDNIH-11019723 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adults diagnosed with Autism Spectrum Disorder who experience difficulties in social interactions.

Less likely to help

Patients without Autism Spectrum Disorder or those who do not experience social motivation deficits may not benefit from this research.

What this research studies

This research investigates the differences in how the brain processes social rewards, like interactions with others, compared to non-social rewards, such as food. By using advanced imaging techniques and optogenetics, the study aims to map the neural circuits involved in these reward systems. It specifically focuses on understanding the deficits in social motivation often seen in individuals with Autism Spectrum Disorder (ASD). The findings could lead to better treatments for enhancing social interactions in those affected by ASD.

Why it matters

Potential benefit: If successful, this research could improve social motivation and interaction for individuals with Autism Spectrum Disorder.

How similar studies have gone: While there has been some success in understanding non-social rewards, the specific investigation of social rewards in relation to ASD is relatively novel and less explored.

Where this research is happening

  • Emory University
    Atlanta, United States
    Active

Researchers

  • Principal investigator: Murugan, Malavika — Emory University
  • Study coordinator: Murugan, Malavika

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.