How the brain predicts outcomes based on cues
The production, learning, and behavioral significance of outcome prediction signaling in the corticostriatal circuit
This study looks at how our brains make guesses about what will happen next based on what we see, focusing on how different parts of the brain work together to understand rewards, and it could help people with decision-making issues or cognitive disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10845550 on NIH RePORTER |
What this research studies
This research investigates how the brain generates predictions about future outcomes based on visual cues, focusing on the corticostriatal circuit. It examines three key aspects of outcome prediction: the amount, timing, and nature of expected rewards. By studying the neural activity in the visual cortex and its connection to the dorsal striatum, the research aims to understand how these brain regions communicate and learn from predictive signals. Patients may benefit from insights into decision-making processes and potential treatments for cognitive disorders related to prediction and reward.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive disorders or difficulties with decision-making and reward processing.
Not a fit: Patients with no cognitive impairments or those not experiencing decision-making difficulties may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of decision-making processes and lead to improved treatments for cognitive disorders.
How similar studies have performed: Previous research has shown success in understanding neural circuits related to decision-making, making this approach promising yet still exploring novel aspects.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Shuler, Marshall Gilmer — Johns Hopkins University
- Study coordinator: Shuler, Marshall Gilmer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.