How the brain maintains memory while learning new information
Stability and Robustness of Hippocampal Representations of Space
This study is looking at how a part of the brain called the hippocampus helps us remember things while also allowing us to learn new information, focusing on special brain cells that help us understand our surroundings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10906310 on NIH RePORTER |
What this research studies
This research investigates how the hippocampus, a key brain region for memory and spatial learning, balances the preservation of existing knowledge with the ability to learn new information. By examining the activity of specific neurons known as place cells, which help form cognitive maps of environments, the study aims to understand the stability and plasticity of these spatial representations over time. The researchers will employ advanced techniques to monitor the activity of these neurons across extended periods, providing insights into how the brain adapts to new experiences while retaining important memories.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or other forms of dementia.
Not a fit: Patients with advanced Alzheimer's disease or severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for memory-related conditions such as Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding hippocampal function and memory, indicating that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Siapas, Athanassios — California Institute of Technology
- Study coordinator: Siapas, Athanassios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.