How the brain learns and adapts over time

Cortical plasticity during reinforcement learning

NIH-funded research University of California, San Diego · NIH-11138558

This project explores how different parts of the brain work together to help us learn and make decisions, which could lead to new ways to help people with learning challenges like ADHD.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego NIH-funded
Lab location1 site (La Jolla, United States)
Project IDNIH-11138558 on NIH RePORTER

What this research studies

Our brains are constantly learning and adjusting, a process called reinforcement learning that is vital for everyday life. This work aims to uncover the brain's secrets behind this learning, from quick adjustments to long-term strategies. We are using advanced tools and mouse models to observe how brain cells and different brain regions communicate during learning. By understanding these fundamental processes, we hope to find new insights into conditions that affect learning and thinking.

Who could benefit from this research

Good fit: Patients who might benefit from future treatments developed from this foundational understanding include those with learning and cognitive disorders, such as Attention Deficit Hyperactivity Disorder.

Not a fit: Patients without learning or cognitive disorders are unlikely to receive direct benefit from this specific research.

Why it matters

Potential benefit: If successful, this work could lead to improved diagnosis and new treatments for learning and cognitive disorders, including conditions like ADHD.

How similar studies have performed: This research builds upon existing knowledge of reinforcement learning and brain function, using novel cutting-edge technologies to gain deeper insights.

Where this research is happening

La Jolla, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Attention deficit hyperactivity disorder
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.