How the Brain Combines Sight and Sound for Clear Communication

Neural substrates of optimal multisensory integration

NIH-funded research University of Pennsylvania · NIH-11143030

This project explores how our brains combine what we see and hear, especially during face-to-face conversations, to help us understand speech better.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11143030 on NIH RePORTER

What this research studies

When we talk face-to-face, our brains naturally combine visual cues from a person's face with the sounds of their voice to help us understand them. This project uses advanced brain imaging (fMRI) and studies epilepsy patients with implanted brain electrodes to understand the specific brain areas involved in this process. Researchers are focusing on a brain region called the posterior superior temporal sulcus/gyrus, which is important for speech perception. They are also looking at how visual illusions can change what we hear, aiming to uncover the fundamental ways our brains process combined sensory information.

Who could benefit from this research

Good fit: Ideal candidates for participation include adults aged 21 and older, particularly those with medically intractable epilepsy who have brain electrodes implanted for treatment.

Not a fit: Patients who are not adults or do not have communication difficulties may not directly benefit from this specific research.

Why it matters

Potential benefit: If successful, this work could lead to better strategies and therapies for individuals with communication challenges, including those with acquired brain injuries.

How similar studies have performed: While the importance of audiovisual speech is well-known, this project uses powerful techniques to explore the specific neural mechanisms and the long-lasting effects of certain illusions in a novel way.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired brain injury
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.