How the brain builds social connections

Characterizing the neural mechanisms of social connection

NIH-funded research Rutgers the State Univ of Nj Newark · NIH-11261093

This work looks at how brain circuits create feelings of connection and how that might help people who feel isolated or struggle with substance use.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionRutgers the State Univ of Nj Newark NIH-funded
Lab location1 site (Newark, United States)
Project IDNIH-11261093 on NIH RePORTER

What this research studies

From a patient's point of view, researchers will examine the brain circuits that make social interactions feel rewarding and help people form bonds. They will use controlled social interaction experiments and neural measurements (including animal models that inform human biology) to trace how shared understanding between people emerges. The team will link those neural signals to behaviors tied to loneliness and substance use to see how social rewards can steer choices. Findings will be used to guide new ways to help people build healthier social ties and reduce harmful coping like drug or alcohol use.

Who could benefit from this research

Good fit: Adults who feel socially isolated or who are struggling with substance use or maladaptive coping related to loneliness would be most relevant.

Not a fit: People without issues of social isolation or substance-related coping, or whose conditions require strictly medical interventions unrelated to social behavior, may not see direct benefit.

Why it matters

Potential benefit: If successful, this work could lead to new treatments or therapies that help people form healthier social connections and reduce substance-related coping.

How similar studies have performed: Animal studies already suggest social opportunity can reduce substance use, but translating the specific brain mechanisms to people is still relatively new.

Where this research is happening

Newark, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.