How the body's internal clock and liver respond to calorie restriction
Official title: Circadian SCN-Liver Axis in the Neuroendocrine Response to Calorie Restriction
Funded at Northwestern University at Chicago · NIH-11023095 · Data updated 2026-11-12
This study looks at how our body's internal clock affects liver health when we eat less food, and it aims to help people understand how changing their diet might improve their energy and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $528,389 |
| NIH project number | 5R01DK132647-03 |
| Project ID | NIH-11023095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the effects of calorie restriction on metabolism and those with metabolic disorders.
✕Less likely to help
Patients who are not undergoing calorie restriction or those with unrelated metabolic conditions may not benefit from this research.
What this research studies
This research investigates the relationship between the body's circadian clock and liver function in response to calorie restriction. It explores how nutrient availability influences metabolic processes and energy conservation during sleep and fasting. By examining the role of specific molecules like NAD+ and SIRT1, the study aims to understand how these factors regulate metabolism and overall health. Patients may benefit from insights into how dietary changes can impact their metabolic health and energy levels.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations that enhance metabolic health and energy conservation for patients.
How similar studies have gone: Previous research has shown promising results in understanding the circadian regulation of metabolism, suggesting that this approach could yield significant insights.
Where this research is happening
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Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Bass, Joseph — Northwestern University at Chicago
- Study coordinator: Bass, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.