How the body's internal clock affects stroke recovery
Circadian Effects in the Stroke Penumbra
This study is looking at how our body's natural clock affects how strokes happen and how well people recover from them, hoping to find better ways to treat stroke patients based on the time of day.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11043414 on NIH RePORTER |
What this research studies
This research investigates how the body's circadian rhythms, or internal biological clocks, influence the progression and recovery from strokes. It focuses on understanding the differences in stroke outcomes based on the time of day when strokes occur, particularly comparing the effects on nocturnal rodents and diurnal humans. The study will explore blood flow, metabolism, and cell death in the brain during strokes at different times of the circadian cycle, aiming to identify optimal conditions for neuroprotection. By mapping these effects, the research seeks to improve treatment strategies for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke, particularly those who can participate in trials during different times of the day.
Not a fit: Patients who have not experienced a stroke or those with other types of neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective stroke treatments tailored to the time of day, improving recovery outcomes for patients.
How similar studies have performed: While the concept of circadian rhythms affecting health is established, this specific approach to stroke recovery is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lo, Eng H. — Massachusetts General Hospital
- Study coordinator: Lo, Eng H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.