How the body's internal clock affects stress responses
Official title: Mechanisms underlying circadian gating of stress responses
Funded at University of California Riverside · NIH-11091328 · Data updated 2026-11-12
This study looks at how our body's internal clock affects how we handle stress throughout the day, using a plant called Arabidopsis to help figure out the science behind it, which could eventually help people manage stress better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $382,755 |
| NIH project number | 1R35GM158312-01 |
| Project ID | NIH-11091328 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with stress-related health conditions that exhibit symptoms influenced by circadian rhythms.
✕Less likely to help
Patients with acute stress responses or those whose conditions are not influenced by circadian rhythms may not benefit from this research.
What this research studies
This research investigates how the circadian clock influences the way organisms, including humans, respond to stress at different times of the day. By studying the model plant Arabidopsis, the researchers aim to uncover the mechanisms that regulate stress tolerance through the timing of gene expression and protein interactions. The study employs a combination of genetics, genomics, and molecular biology techniques to identify key regulators involved in this process. Understanding these mechanisms could lead to better management of stress-related conditions in humans.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for stress-related diseases by optimizing timing in therapeutic interventions.
How similar studies have gone: Previous research has shown promising results in understanding circadian rhythms and their impact on health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Nagel, Dawn H — University of California Riverside
- Study coordinator: Nagel, Dawn H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.