How the body's internal clock affects nutrient metabolism and muscle health
Official title: Circadian clock and temporal control in nutrient metabolism
Funded at Beckman Research Institute/city of Hope · NIH-10917270 · Data updated 2026-11-12
This study is looking at how our body's internal clock affects how our muscles use nutrients, especially when things go out of sync, which can lead to problems like insulin resistance and obesity, and it hopes to find new ways to help people manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $435,663 |
| NIH project number | 5R01DK137515-02 |
| Project ID | NIH-10917270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing metabolic disorders such as obesity or insulin resistance.
✕Less likely to help
Patients with stable metabolic conditions who do not experience circadian disruptions may not benefit from this research.
What this research studies
This research investigates the role of the circadian clock in regulating nutrient metabolism, particularly in skeletal muscle. It aims to understand how disruptions in this internal clock can lead to conditions like insulin resistance and obesity. By studying the molecular mechanisms involved, including the signaling pathways that control muscle growth and metabolism, the research seeks to uncover how circadian misalignment contributes to muscle wasting and metabolic dysfunction. Patients may benefit from insights that could lead to new strategies for managing metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and insulin resistance by targeting circadian rhythms.
How similar studies have gone: Previous research has shown promising results in understanding the impact of circadian rhythms on metabolism, suggesting that this approach could yield significant insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Ma, Ke — Beckman Research Institute/city of Hope
- Study coordinator: Ma, Ke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.