How the body's internal clock affects muscle health
Circadian Clock and Muscle Health
This study is looking at how our body's internal clock affects muscle strength and health, especially when something goes wrong with it, and it aims to help people understand how keeping a regular daily routine might boost their muscle function and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11031343 on NIH RePORTER |
What this research studies
This research investigates the role of the muscle circadian clock in regulating gene expression and its impact on muscle strength and overall health. It focuses on understanding how disruptions in this clock, particularly through the loss of the Bmal1 gene, can lead to muscle weakness and increased mortality. The researchers will explore the interactions between muscle-specific genes and the circadian clock to uncover mechanisms that link these disruptions to muscle health. Patients may benefit from insights into how maintaining a healthy circadian rhythm could improve muscle function and systemic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing muscle weakness or related health issues.
Not a fit: Patients with no muscle health concerns or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing muscle health and preventing weakness in adults.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between circadian rhythms and muscle health, suggesting that this approach could yield significant insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Esser, Karyn a — University of Florida
- Study coordinator: Esser, Karyn a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.